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Importantly, in this study these substances did not show any toxic effects against human lymphocytes [19]

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It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]

10.1111/j.1463-1326.2009.01108.x 44 ShinS.Le LayJ.EverettL